Checking organ health in sickle cell patients after stem cell transplant

This study is examining whether a stem cell transplant or gene therapy helps repair organ damage caused by sickle cell disease. Researchers will compare people who receive these potentially curative treatments to those who continue with standard care, looking at how the heart, lungs, kidneys, liver, and brain function over 2 years.

Sickle cell disease damages multiple organs over time and can shorten life span. While stem cell transplants and gene therapy show promise as cures, doctors need to understand exactly how these treatments affect organ recovery and whether people truly benefit in the long term.