Plain-English translation of NCT05213572 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is checking how well different organs work after adults with sickle cell disease receive curative treatments like stem cell transplants or gene therapy. Researchers will do detailed heart, lung, liver, kidney, and brain scans at the start and again 2 years later, comparing people who receive curative treatment to those who continue with standard care. The goal is to understand how these life-changing treatments affect your body over time.
Sickle cell disease damages organs and shortens lifespan, but newer curative treatments like stem cell transplants offer hope for a cure. However, doctors don't yet fully understand how these treatments affect organ function in the long run, so this study will provide that critical information.
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You will visit the NIH Clinical Center for detailed testing of your heart, lungs, liver, kidneys, and brain function. This includes heart scans, lung function tests, blood work, and possibly MRI or other imaging. You'll be tested at the beginning of the study and again 2 years later, so the researchers can see how your organs are doing over time. The study compares people receiving curative treatment to those on standard care to understand the long-term effects of these newer therapies.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States