Plain-English translation of NCT05217940 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is evaluating the best ways to screen for anal cancer in women who have a history of HPV-related genital disease. Researchers will use three screening approaches—cell samples, HPV testing, and a visual examination called high-resolution anoscopy—to understand how often anal cancer precursors appear in this group and how well these screening tools work.
Women who have had HPV-related genital growths or cancers may be at higher risk for anal cancer, but there is very little information about whether and how to screen this group. This trial aims to find out if screening is helpful and which screening methods work best.
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You would visit the study clinic at baseline and then return for follow-up visits at 12 and 24 months. At each visit, you would have anal cell samples collected, HPV testing performed, and a visual examination of your anal tissue. The entire study runs for two years, and researchers will also ask about your experience with the screening process and whether you found it acceptable.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States
Sponsor
Icahn School of Medicine at Mount Sinai
Collaborators
M.D. Anderson Cancer Center, Medical University of South Carolina
Enrollment target
~300 participants
Started
March 2022
Primary completion
January 2027
Age range
35 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Daniela Solis
Icahn School of Medicine at Mount Sinai
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.