Plain-English translation of NCT05222620 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether receiving radiation treatment in multiple sessions over a week works better than receiving it all in one session for brain tumors that have spread from cancer elsewhere in your body. Researchers want to understand which approach helps patients live longer, causes fewer side effects, and maintains a better quality of life. Both types of radiation treatment are already used in practice, but this study will help doctors understand which approach is better for patients like you.
When cancer spreads to the brain, doctors use a precise type of radiation called stereotactic radiosurgery to target the tumors. However, it's not yet clear whether giving this treatment in one session or splitting it into multiple sessions produces better results with fewer complications.
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If you enroll, you will be randomly assigned to receive either one radiation treatment session or 3 to 5 radiation sessions spread over up to 8 days. Both groups will have MRI brain scans before treatment and during follow-up appointments to monitor how the tumors are responding. The trial team will also check in on your symptoms, side effects, and quality of life over time to compare how well each approach works for you.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
United States