Plain-English translation of NCT05223413 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Some chemotherapy drugs used to treat lymphoma, called anthracyclines, can harm the heart over time. This study is testing whether a simple procedure called remote ischemic conditioning—done weekly with a blood pressure cuff on your arm—can protect your heart during and after treatment. Half of the participants will receive the real procedure, and half will receive a sham (fake) version, so doctors can see if it truly helps.
Anthracycline chemotherapy saves lives but can weaken the heart muscle in some patients. Doctors need a safe, easy way to prevent this heart damage during cancer treatment.
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You will receive weekly sessions of the study procedure during your entire chemotherapy treatment. Each session involves four cycles of a blood pressure cuff inflating for 5 minutes and deflating for 5 minutes on your arm. You will have heart imaging scans (MRI) and blood tests at several timepoints: before chemotherapy starts, after your third chemotherapy cycle, during your final cycle, and 9 weeks after finishing treatment. You'll also be checked for any heart-related problems at follow-up appointments for up to 3.5 years after treatment ends.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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