Recruiting

Brain Stimulation and Training to Help Veterans Lose Weight

Plain-English translation of NCT05225233 on ClinicalTrials.gov ↗ · Source last updated April 2026 · Translation generated June 2026 · How we translate trials

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This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether transcranial direct current stimulation (tDCS)—a non-invasive technique that uses mild electrical current on the scalp—combined with cognitive training can help veterans with obesity lose weight and reduce impulsive eating behaviors. You would receive this treatment alongside a structured weight loss program. The study aims to understand whether this brain stimulation approach can enhance your ability to make healthier food choices and stick to your weight loss goals.

Many people struggle with weight loss because impulsive eating habits are hard to overcome with willpower alone. This treatment is being tested because researchers believe that stimulating specific brain areas involved in decision-making, combined with mental training exercises, might help retrain the brain to reduce food cravings and impulsive eating—potentially making weight loss more achievable.

Do you qualify?

You likely qualify if…

you are a veteran enrolled in a weight management program at the Minneapolis VA Health Care System
you have obesity (a BMI greater than 30, or greater than 27 with a weight-related health condition)
you are between 18 and 80 years old
you are able to understand English and follow study procedures on your own
if you are a woman of childbearing age, you are willing to use reliable birth control during the study

You likely don't qualify if…

you have a history of seizures, serious head injury, head surgery, or significant brain disorders
you have frequent severe headaches or scalp conditions like eczema
you have metal in your head (except dental work) or implanted medical devices like pacemakers
you are pregnant, actively dealing with substance dependence, or have moderate-to-severe depression
you have an untreated metabolic or hormonal condition (like uncontrolled thyroid disease or diabetes with very high blood sugar) that could affect your weight

What participation looks like

You would attend 13 study visits over approximately 4 months. The main treatment involves 10 sessions of brain stimulation paired with cognitive training exercises, completed over three weeks—one hour per session. During each session, you'll receive either active or sham (placebo) brain stimulation for 20 minutes at the start, followed by 46 minutes of mental training exercises designed to improve decision-making. You'll also be part of a structured weight loss program throughout. Testing visits will occur before treatment starts, during week 3, at week 9, and at the end to measure changes in your impulsivity and weight.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

United States

Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis, Minnesota