Plain-English translation of NCT05238610 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing whether closing a small hole in the heart (called a PFO) using a minimally invasive procedure can help prevent another stroke in older adults who've had a stroke with no clear cause. All participants will take blood-thinning medications like aspirin and clopidogrel. Some will also receive a procedure to close the heart opening, while others will take the medication alone. The study will monitor everyone closely for irregular heart rhythms using heart monitors.
Some older adults have strokes that doctors can't fully explain, and researchers suspect a small opening between chambers of the heart may be allowing clots to slip through. This trial wants to see if closing that opening can reduce the risk of another stroke better than medication alone.
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You'll be enrolled at one of 20 hospitals in Korea and monitored with a small heart-monitoring device (inserted under the skin) or regular heart tracings to detect irregular rhythms. Over 3–6 months, your doctors will decide whether to perform the heart-closing procedure based on what they find and your individual situation. You'll take daily blood-thinning medications, and if an irregular heartbeat is detected, you may switch to a different type of blood thinner. Throughout the study, you'll have regular follow-up visits and monitoring to track your progress and watch for any new strokes.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
South Korea
Sponsor
Asan Medical Center
Collaborators
National Evidence-Based Healthcare Collaborating Agency
Enrollment target
~1,200 participants
Started
January 2022
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
60 Years and older
Last updated on clinicaltrials.gov in February 2022.
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Central contact
Sun U Kwon, MD. PhD
Asan Medical Center
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