Plain-English translation of NCT05239338 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →The PREFACE Study is a long-term research project designed to understand how colorectal cancer and its treatment affect fertility, sexual health, and quality of life in people diagnosed before age 50. Researchers will follow participants from before treatment begins through 36 months after treatment ends, collecting health information, answering questions about your wellbeing, and gathering biological samples (like blood) at set timepoints. This information will help doctors better support young cancer survivors and preserve their fertility options.
Colorectal cancer is increasingly common in younger adults, and doctors don't fully understand how cancer treatments affect fertility and sexual health in this age group. This study exists to fill that gap so future patients can make informed decisions about protecting their fertility before treatment starts.
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You would meet with the research team before your cancer treatment begins, then return for follow-up visits at set intervals: when your treatment is complete, and then at 9, 18, and 36 months afterward. At each visit, you'll answer questions about your health, fertility concerns, and sexual wellbeing, and provide blood or tissue samples. Over three years, you'll help researchers understand how young adults navigate cancer treatment and fertility preservation — information that could help countless future patients.
AI-generated summary from trial data · Aug 14, 2026 · Not medical advice
United States
Sponsor
Andreana Holowatyj, PhD, MSCI
Enrollment target
~1,000 participants
Started
December 2021
Primary completion
December 2036
Age range
18 Years – 49 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
PREFACE Study Coordinator (Rebecca B.)
Vanderbilt-Ingram Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.