Plain-English translation of NCT05239624 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether combined with can help people with advanced bladder cancer before they have surgery to remove their bladder. Both medications work by helping your immune system recognize and attack cancer cells. Researchers believe that using these two drugs together may work better than either one alone at shrinking tumors and eliminating cancer in the lymph nodes.
Bladder cancer that has spread to nearby lymph nodes is serious and difficult to treat. Doctors want to know if this combination of medications can shrink the cancer before surgery, which might improve outcomes and help more patients survive.
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You would receive two medications: by infusion on days 1 and 8 of each 3-week cycle, and by infusion on day 1 of each cycle. This continues for up to 6 cycles (about 4.5 months), with imaging scans to check how your cancer is responding. After completing treatment, you would have surgery to remove your bladder, then continue with one of the medications alone for about 11 more months to complete a year of therapy.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
United States