Plain-English translation of NCT05240352 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing transcranial direct-current stimulation (tDCS)—a noninvasive procedure that uses mild electrical currents to stimulate specific brain regions—to help restore the ability to feel pleasure in people with bipolar disorder. Researchers will use brain imaging to see how the treatment affects the brain circuits responsible for reward and enjoyment, and whether those changes relate to improvements in your symptoms.
Many people with bipolar depression lose the ability to feel pleasure from activities they once enjoyed, and current treatments don't always fully address this problem. This trial aims to understand whether tDCS can safely and effectively restore these reward circuits, and to develop better ways to personalize the treatment for each individual.
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You will receive sessions of tDCS, a painless procedure where electrodes are placed on your scalp to deliver mild electrical stimulation. Some participants will receive active treatment while others receive a sham (placebo) version, so you won't know which you're getting. You'll also undergo brain imaging scans before and after treatment to allow researchers to measure changes in your brain's reward circuits and track any improvements in your ability to feel pleasure.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States