Plain-English translation of NCT05247125 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether a combination of blue light exposure and melatonin can help people recover better after an ischemic stroke (when a blood clot blocks blood flow to the brain). Researchers believe that helping your body's natural sleep-wake cycle may improve how well your brain heals after a stroke. The study will compare people who receive melatonin alone, blue light alone, both treatments together, or neither (a placebo group) to see which approach works best.
After a stroke, sleep problems are common and can interfere with brain recovery. This medication and light therapy are thought to help restore your body's natural circadian rhythm (your internal 24-hour clock), which may boost the brain's ability to heal itself and reduce long-term disability.
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If you join this study, you'll be randomly assigned to one of four groups for 14 days: some participants will receive melatonin pills (taken one hour before bed) plus morning blue light therapy, others will receive melatonin with placebo light, blue light with placebo pills, or both placebos. You'll have blood tests and sleep assessments at the start and again at day 14, and your stroke recovery will be tracked again at 3 months. Throughout the study, researchers will monitor how you're sleeping and how well you're recovering.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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