Plain-English translation of NCT05250648 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether adding a heated chemotherapy treatment called Mitomycin-C during surgery helps people with colon cancer that has spread to the abdominal lining. The surgery removes visible cancer, and the medication is heated and washed over the abdomen for 90 minutes to kill any remaining cancer cells. You would be randomly assigned to either receive this heated chemotherapy after surgery or to have surgery alone.
A previous major study suggested that this heated chemotherapy might not help people live longer, but doctors believe that study had flaws. This new trial is designed to test more carefully whether this treatment really does help prevent the cancer from coming back in the abdomen.
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You would have surgery to remove all visible cancer from your abdomen. During surgery, the surgeon would confirm that all cancer has been removed and that you meet the study criteria. You would then be randomly assigned to receive either heated chemotherapy or no heated chemotherapy. You would continue with standard chemotherapy before and after surgery as recommended by your doctor, and you would have regular follow-up visits to monitor your health and check for cancer recurrence.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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