Plain-English translation of NCT05254574 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a wearable device that delivers sustained ultrasound therapy, combined with a diclofenac patch (a topical pain-relief medication), to help manage arthritis pain. The study will compare how well this combination treatment works for people with mild to moderate arthritis in various joints, measuring changes in pain levels and daily functioning over 8 weeks. Researchers want to know if this non-invasive approach can be an effective way to control arthritis symptoms.
Many people with arthritis struggle with chronic pain that affects their quality of life, and current treatment options don't work equally well for everyone. This trial explores whether combining continuous ultrasound therapy with topical pain relief might offer a new, wearable option that patients can use at home without relying on oral pain medications.
You likely qualify if…
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If you join this study, you will wear a wearable ultrasound device for at least 4 hours a day, at least 5 days a week, for 8 weeks—you can wear it at home or during normal daily activities (just not while bathing or swimming). You will also apply a medicated patch to the affected joint area during treatment. Your pain levels and how well you can move and function will be measured at the beginning and end of the study to see how much the treatment helps.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States
Phase
Safety & dosing
Sponsor
ZetrOZ, Inc.
Enrollment target
~200 participants
Started
February 2022
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
35 Years – 85 Years
Last updated on clinicaltrials.gov in February 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
George K. Lewis, Ph.D.
James A. Haley Veterans Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.