Recruiting

Testing a new injection for severe itching with no known cause

Plain-English translation of NCT05263206 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated September 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This clinical trial is testing a medication called to see if it can help adults with chronic itching that has no clear medical explanation. is an injection you would receive every two weeks, along with continuing your current antihistamine and moisturizer routine. The study wants to find out if this medication is safe and whether it actually reduces the severe itching that hasn't improved with other treatments.

Chronic itching with no known cause is difficult to treat, and many people don't get relief from standard antihistamines and skin care alone. This trial exists to see whether this medication, which works differently than typical itch treatments, might help people who have suffered with severe itching for months or years.

Do you qualify?

You likely qualify if…

you are between 18 and 90 years old
you have had severe itching for at least 6 months and doctors cannot find a specific cause (such as a skin disease, nerve damage, or medication side effect)
your itching affects at least two areas of your body, such as your legs, arms, or trunk
your itching has been severe and has not improved well with previous treatments you have tried
you rate your worst itching as 7 or higher on a scale of 0 to 10

You likely don't qualify if…

you have a serious infection (such as active tuberculosis) or a weakened immune system
you have HIV or are at high risk for serious parasitic infections
you have been treated with dupilumab before or participated in a previous dupilumab study
you have active cancer or were treated for cancer in the past 5 years (with some exceptions)
you are on kidney dialysis or have other severe medical conditions that your doctor thinks would make it unsafe for you to participate

What participation looks like

You would be in the study for up to 44 weeks. Half of participants will receive the new medication by injection every two weeks (starting with a loading dose), and half will receive a placebo injection on the same schedule. All participants continue taking their current non-sedative antihistamine and moisturizer. You will have regular visits to report how your itching is affecting you and to be checked for any side effects.

AI-generated summary from trial data · Sep 4, 2026 · Not medical advice

Testing a new injection for severe itching with no known cause

What is this trial?

Do you qualify?

What participation looks like

Trial locations(93 sites)