Plain-English translation of NCT05275608 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 2 research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing whether a very low calorie ketogenic diet can help people who have type 2 diabetes, obesity, and fatty liver disease all at the same time. Researchers will compare this diet to a Mediterranean-style eating plan to see which one works better at improving blood sugar control, weight, and liver health. The study will measure many aspects of health, including changes in gut bacteria, blood markers, and body composition.
Many people struggle with multiple related health problems—diabetes, excess weight, and fatty liver disease—that feed into each other. Early research suggests this specialized eating approach may help treat all three conditions at once, but researchers need to test it directly against a proven healthy diet to know if it truly works better.
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If you join, you'll be randomly assigned to follow either the ketogenic diet or the Mediterranean diet for the study period. You'll continue seeing your regular doctors and taking your current diabetes medications as usual. The study involves regular visits where researchers will collect blood samples, stool samples, and urine samples; take measurements of your body and fat distribution; and perform ultrasounds and other imaging tests to track changes in your liver and overall health.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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