Plain-English translation of NCT05277688 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
After surgery for early-stage cervical cancer, doctors often give radiation therapy to lower the chance of cancer coming back. This trial is testing whether adding the chemotherapy drug cisplatin to the radiation works better than radiation alone. The study will enroll 340 patients and track whether adding this medication helps prevent cancer recurrence.
Some early-stage cervical cancers have features that make them more likely to return even after surgery and standard radiation therapy. Researchers want to know if combining chemotherapy with radiation can better protect patients with these higher-risk features, particularly those with certain types of cancer cells.
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You will be randomly assigned to receive either radiation therapy alone or radiation therapy combined with weekly chemotherapy infusions. Both treatments involve five days of radiation per week for several weeks, delivered using modern imaging technology (IMRT). If you are in the combination group, you will also receive cisplatin by vein once per week during your radiation. The study team will monitor you regularly during treatment and follow you afterward to see if the cancer returns.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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