Plain-English translation of NCT05282277 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This research study is testing whether estradiol, a hormone that naturally declines during menopause, can help women who experience depression, loss of pleasure in activities, or psychotic symptoms during the menopause transition. Researchers believe that low estradiol levels may affect how the brain processes reward and motivation. The study will use advanced brain imaging to see how the medication affects brain activity related to pleasure and reward.
Many women experience depression, loss of interest in activities, or even psychosis as they enter menopause, but we don't fully understand why or how to treat it effectively. This study aims to understand whether restoring hormone levels can help these symptoms and how the medication works in the brain.
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If enrolled, you would be randomly assigned to wear either an estradiol hormone patch or a placebo patch for 3 weeks, followed by 1 additional week where you may also take progesterone. Throughout the study, you will undergo brain imaging scans (PET and MRI) to measure how your brain responds to rewards, and complete questionnaires about your mood and symptoms. The entire study lasts about 4 weeks, with clinic visits for assessments and imaging appointments.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
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