Plain-English translation of NCT05283382 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This study is testing whether cannabidiol, a natural compound found in cannabis plants, can help people with social anxiety overcome fear responses more effectively. Researchers will teach participants to associate one face with a mild electric shock, then test whether the medication helps them unlearn that fearful association. The study involves one single dose of the medication or a placebo.
Many people with anxiety struggle to overcome fearful memories and responses, even after the threat has passed. Researchers want to know if this medication might help the brain 'reset' these fear pathways more quickly, which could eventually lead to better anxiety treatments.
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You will first complete a screening to confirm you have elevated social anxiety. Then you'll be shown two faces on a computer screen—one will occasionally be paired with a mild electric shock to your wrist, and one will not. After you learn this association, you'll receive either the medication or a placebo as a single dose. Finally, you'll see both faces again without any shocks, while researchers measure your fear response through skin conductance and by asking you to rate your fear level on a scale.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
United States