Recruiting

Advanced imaging and proton radiation therapy for returning brain cancer

Plain-English translation of NCT05284643 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether a special type of MRI scan called spectroscopic MRI can help doctors find hidden cancer cells in the brain, allowing them to deliver more targeted radiation therapy. You would also receive (a medication that helps block new blood vessels feeding the cancer) along with proton radiation therapy, which is a precise form of radiation designed to minimize damage to healthy brain tissue.

Glioblastoma is an aggressive brain cancer that often comes back even after initial treatment. This trial is exploring whether the new imaging technique can help doctors target remaining or hidden cancer cells more accurately, potentially improving outcomes while reducing side effects.

Do you qualify?

You likely qualify if…

you have been diagnosed with glioblastoma that has returned after previous treatment
your cancer area measures 6 centimeters or smaller on imaging scans
you have already received prior radiation therapy to the brain
you are at least 18 years old and in generally stable health (performance status 0-2)
you are able to have MRI scans and can provide written informed consent
you are willing to use effective contraception during treatment and for at least 6 months after, if of childbearing potential

You likely don't qualify if…

you have received prior brain radiation therapy fewer than four to six months ago (depending on where the cancer is located)
you are pregnant or breastfeeding
you have a life expectancy of less than 12 weeks
you are unable to undergo MRI scans
you have taken certain chemotherapy drugs without waiting the required time between your last dose and study start

What participation looks like

You would receive a special spectroscopic MRI scan to help identify cancer cells, then undergo radiation therapy delivered in 10 sessions over two weeks using proton therapy (which targets cancer more precisely). You would also receive , either as an injection or infusion, starting before radiation begins and continuing as your doctor recommends. Your doctor will monitor your health throughout treatment and afterward.

AI-generated summary from trial data · Aug 3, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Miami, Miami, Florida