Plain-English translation of NCT05285917 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
The PUSHUP trial is testing , a medication that can reduce pain and complications from sickle cell disease in children. This study will figure out the best way to use this treatment in Africa, where lab resources may be limited. Researchers will compare two different ways of starting the medication—one based on weight alone, and one tailored to each child's individual needs.
can help children with sickle cell disease feel better and live longer, but many families in Africa don't have access to it because doctors aren't sure how to dose it safely without frequent blood tests. This trial will create clear, practical guidelines so that this medication can be used widely, even in areas with fewer medical resources.
You likely qualify if…
You likely don't qualify if…
If you join, you will be randomly assigned to start the medication using one of two dosing methods. You will visit the clinic regularly for check-ups and to have your blood checked using a portable machine that measures the medication level in your body. The study team will adjust your dose over time based on your individual response and blood results, and will track how you feel and how often you have pain or other symptoms related to sickle cell disease.
AI-generated summary from trial data · Sep 4, 2026 · Not medical advice
Angola