Plain-English translation of NCT05287321 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether combining aspirin and can help prevent preeclampsia—a serious blood pressure condition that can develop during pregnancy. The study focuses on women who have already experienced preeclampsia, fetal growth restriction, or pregnancy loss in a previous pregnancy, and are therefore at higher risk for these complications happening again. Researchers want to see if this two-medication approach works better than aspirin alone.
Preeclampsia and related pregnancy complications can be life-threatening for both mother and baby. Women who have had these problems before are much more likely to experience them again in future pregnancies. This medication combination shows promise in early research, and this trial will test whether it can actually prevent these serious complications from happening a second time.
You likely qualify if…
You likely don't qualify if…
If you qualify and enroll, you will take the study medications by mouth once daily starting between weeks 12 and 22 of your pregnancy, and continue until week 36. You will be asked to take the medication reliably—missing doses should be rare. You'll have regular visits with the research team to check on your health and your baby's development, and they will monitor your blood pressure and other signs closely throughout your pregnancy. The study will track whether you develop preeclampsia or other complications.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
South Korea
Phase
Large-scale testing
Sponsor
Yoo-min Kim
Collaborators
Ministry of Health & Welfare, Korea
Enrollment target
~58 participants
Started
May 2022
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
19 Years – 50 Years
Sex
Female only
Last updated on clinicaltrials.gov in December 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yoo-min Kim, MD
Chung-Ang University Gwangmyeong Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.