Plain-English translation of NCT05288790 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a probiotic supplement in people living with HIV who drink heavily. Heavy alcohol use can damage the bacteria in your gut and increase heart disease risk, and researchers believe this probiotic may help restore healthy gut bacteria and reduce inflammation. All participants will also receive counseling to help with alcohol use.
People with HIV who drink heavily have much higher rates of heart disease and early death. Recent research shows that alcohol damages the healthy bacteria in the gut, which then triggers inflammation and other harmful changes throughout the body. This trial wants to know if restoring healthy gut bacteria with this medication can prevent those dangerous changes.
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You will receive either the probiotic supplement or a placebo (inactive pill) for 6 months. You'll attend study visits where researchers will take blood samples to measure gut health, inflammation markers, and heart disease risk. All participants also receive counseling focused on reducing alcohol use. The study will check your progress at 6 months to see if the treatment is working.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
United States
Testing effectiveness
Sponsor
Vanderbilt University Medical Center
Collaborators
University of Louisville, Boston University
Enrollment target
~250 participants
Started
September 2023
Primary completion
August 2026
Age range
18 Years – 89 Years
Last updated on clinicaltrials.gov in June 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Grace Wallace, BS
Vanderbilt University Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.