Plain-English translation of NCT05295888 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new treatment called Temporal Interference (TI) stimulation for people with moderate to severe depression. TI uses two gentle electrical currents applied to your scalp that work together to stimulate a specific region deep in the brain called the subgenual cingulate cortex, which researchers believe plays an important role in depression. The goal is to see if this non-invasive brain stimulation can help reduce depression symptoms while being safe and well-tolerated.
Current depression treatments often have side effects and don't work for everyone, especially people with treatment-resistant depression. This trial exists because doctors need new treatment options with different approaches, and this medication cannot reach deep brain areas that may be important in depression using older technology.
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You would receive 10 daily treatment sessions over about two weeks, each lasting 30 minutes. During each session, you would receive either the brain stimulation treatment or a placebo (sham) stimulation through electrodes placed on your scalp while watching emotional film clips. The researchers will also perform brain imaging scans and electrical recordings to measure how the treatment affects your brain activity. You'll be assessed for safety, tolerability, and changes in your depression symptoms.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
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