Plain-English translation of NCT05299710 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial tests whether removing and freezing ovarian tissue (eggs and reproductive tissue) before cancer treatment can help girls preserve their ability to have children later in life. The frozen tissue would be stored safely and could potentially be used in the future when new fertility restoration techniques become available. A small sample of the tissue may also be used for research to improve freezing and storage methods.
Many cancer treatments like chemotherapy and radiation can permanently damage or destroy a girl's ovaries, making it impossible to become pregnant naturally. This trial exists to offer a way to preserve fertility before these treatments begin, giving girls options for having biological children when they are ready as adults.
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If you enroll, you will have a pre-surgery evaluation at the hospital or clinic. Then, under general anesthesia (while you're asleep), doctors will perform a minimally invasive surgical procedure called laparoscopy to remove one ovary or a small sample of ovarian tissue. The tissue is then frozen using special techniques to preserve it for future use. You will also be asked to donate a tiny piece of tissue for research to help improve storage methods. After surgery, you will be enrolled in a long-term tracking program with yearly surveys to monitor outcomes.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Sponsor
Erin Rowell
Collaborators
Ann & Robert H Lurie Children's Hospital of Chicago
Enrollment target
~250 participants
Started
May 2018
Primary completion
December 2030
Sex
Female only
Last updated on clinicaltrials.gov in November 2024.
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Central contact
Sara Reyes
Lurie Childrens Hospital
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