Plain-English translation of NCT05299749 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a new approach called real-time brain imaging neurofeedback to help people with schizophrenia who experience persistent auditory hallucinations (hearing voices) despite taking medication. During the treatment, you'll receive brain scans that show your brain activity in real time, and you'll learn techniques to control a specific area of your brain linked to hearing voices. The goal is to help reduce or stop these hallucinations.
Many people with schizophrenia continue to hear voices even when taking antipsychotic medications, which significantly impacts their quality of life. This trial exists to test whether training people to control their own brain activity through real-time feedback could offer relief when standard medications alone are not enough.
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You will participate in 5 sessions of brain imaging while practicing techniques to control your brain activity. In each session, you'll lie in an MRI scanner while receiving real-time feedback about your brain activity, helping you learn to regulate the specific brain region linked to hearing voices. The study will also include brain scans and tests to measure changes in your symptoms and brain function over time.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Boston VA Research Institute, Inc.
Collaborators
Mclean Hospital, Northeastern University
Enrollment target
~104 participants
Started
March 2022
Primary completion
June 2026
Age range
18 Years – 55 Years
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
margaret niznikiewicz, PhD
Boston VA Research Institute, Inc.
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.