Plain-English translation of NCT05304208 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
The ENSURE trial is testing a new treatment approach for pleural mesothelioma (a cancer affecting the lining of the lungs). Researchers will collect your immune cells, train them in the laboratory to recognize cancer, and inject them back into your body as a vaccine called . You'll receive this therapy both before and after surgery to remove the cancerous tissue.
Pleural mesothelioma is a serious cancer that currently has limited treatment options. This trial is exploring whether boosting your own immune system to fight the cancer cells — combined with surgery — can help improve outcomes and survival.
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First, doctors will collect some of your blood cells before you start chemotherapy. After you finish standard chemotherapy, you'll receive five injections of the immune cell therapy spaced over several weeks. Four weeks after your first injection, you'll undergo surgery to remove the cancerous tissue lining your lungs. After surgery, you'll receive three more injections of the therapy. The entire process takes several months, and you'll need to visit the study center regularly for vaccinations and medical check-ups.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
Netherlands