Plain-English translation of NCT05305092 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →This research study is investigating whether chemotherapy or endocrine therapy (hormone therapy) causes changes in thinking, memory, and brain function in premenopausal women with early-stage breast cancer. Researchers will use advanced brain imaging called PET/MRI scans combined with thinking and memory tests to detect these changes. The goal is to identify which patients are at risk so doctors can better plan treatment in the future.
Many breast cancer survivors report problems with memory and concentration after treatment—sometimes called 'chemo brain'—but doctors don't yet have a reliable way to predict who will be affected. This study aims to find early warning signs so that patients at risk can be identified and supported before serious cognitive decline occurs.
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You would be enrolled before starting chemotherapy or hormone therapy. Your participation would involve undergoing advanced brain imaging scans (PET/MRI) and completing various cognitive and thinking tests at different time points. The study compares three groups: women receiving chemotherapy plus hormone therapy, women receiving only hormone therapy, and healthy women without cancer. The scans and tests help researchers see how your brain structure, function, and metabolism change over time with treatment.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
China
Sponsor
Tang-Du Hospital
Collaborators
Xi'an Jiaotong University
Enrollment target
~90 participants
Started
May 2022
Primary completion
May 2027
Sex
Female only
Last updated on clinicaltrials.gov in July 2022.
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Central contact
Menghui Yuan, phd
Tang-Du Hospital
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