Plain-English translation of NCT05305313 on ClinicalTrials.gov ↗ ·
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing the best way to dose , a common intravenous anesthesia medication, for people with obesity undergoing surgery. The study compares two calculation methods — one based on total body weight and one based on adjusted body weight — using an automated system that continuously monitors and adjusts the medication dose during surgery. The goal is to find which method keeps patients safely and comfortably asleep while avoiding too much medication in their system.
People with obesity process anesthesia differently than others because their body composition — including more fat tissue — affects how the medication spreads through the body and gets cleared. This can make it hard to give the right dose: too little and the patient may wake up during surgery, too much and recovery can be delayed with potential heart problems. Researchers want to find the most accurate dosing method for this population.
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If you enroll, you would receive standard anesthesia care during your scheduled surgery, but the anesthesia would be delivered using an automated closed-loop system that continuously adjusts the medication dose based on your body's response. You would be randomly assigned to one of two dosing calculation groups — the difference is simply which mathematical formula the automated system uses to determine your dose. You would not need any extra visits or tests beyond your normal pre-surgery appointments; the study takes place during your surgery itself.
AI-generated summary from trial data · Aug 15, 2026 · Not medical advice
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