Plain-English translation of NCT05314114 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether some women with triple-negative or HER2-positive breast cancer can avoid lymph node surgery after chemotherapy. Doctors have noticed that about half of patients who receive chemotherapy before surgery have their lymph node disease completely eliminated. This trial asks: if your breast cancer completely disappears after chemotherapy, do you still need lymph node surgery, or could you safely skip it?
Current guidelines say all patients must have lymph node surgery after chemotherapy, even though many won't have any cancer remaining there. Lymph node surgery can cause pain, numbness, and swelling in the arm and chest for months afterward. This trial exists to see if we can spare patients from this surgery when it's not medically necessary.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you will receive standard chemotherapy followed by breast-conserving surgery—but you will skip the lymph node biopsy or removal that is normally done. Researchers will follow you over time to monitor your health and make sure you remain cancer-free. The study will take place over 36 months at a single center in China, with regular check-ups to track your long-term outcome.
AI-generated summary from trial data · Sep 1, 2026 · Not medical advice
China