Plain-English translation of NCT05316103 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a special imaging tool called probe-based confocal laser endomicroscopy (pCLE) can help doctors more accurately determine if rectal cancer has been completely eliminated after chemotherapy and radiation treatment. The new imaging method works by using a fluorescent dye and a tiny camera to look at the scarred area in real time, allowing doctors to spot any remaining cancer cells that traditional biopsies might miss.
After radiation and chemotherapy, it is hard for doctors to tell whether the cancer is truly gone just by looking at the scarred tissue. Currently, doctors are right only about 36% of the time when they think the cancer is completely eliminated. This trial aims to improve this accuracy so that doctors can confidently decide whether patients need surgery or can safely skip it.
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You will undergo two types of biopsies during a single procedure: a standard endoscopic biopsy (where a small tissue sample is taken the usual way) and the new imaging-guided biopsy using the pCLE tool. Both procedures happen at the same visit, and tissue samples are sent to the lab for testing. After your scheduled surgery, doctors will compare the biopsy results with the actual pathology findings to see how accurate each method was.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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