Weight management combined with hormone treatment for uterine lining overgrowth

This trial is testing whether combining weight management with hormone treatment—either megestrol acetate (a progesterone medication taken by mouth) or a levonorgestrel intrauterine system (a device placed in the uterus)—can help treat abnormal uterine lining overgrowth in women who are overweight or obese. The study focuses on women who want to preserve their ability to have children. Researchers believe that losing weight alongside this medication or device may improve treatment success and pregnancy chances.

Abnormal uterine lining overgrowth is a serious condition, but many women want to avoid surgery to remove the uterus so they can still have children. While hormone treatment works for most women, about 20–30% don't respond well or take a very long time to improve. Being overweight or obese makes treatment less likely to work and pregnancy less likely to happen. This trial is designed to see if adding structured weight management (diet, exercise, and lifestyle support) to the hormone treatment can make it more effective.