Plain-English translation of NCT05319067 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how trimethoprim-sulfamethoxazole, an antibiotic given long-term to prevent urinary tract infections in young children with vesicoureteral reflux, affects the healthy bacteria in the gut. This study will compare the gut bacteria of children taking this medication with children who have a similar urinary condition but aren't on antibiotics, and with completely healthy children. The goal is to see whether long-term antibiotic use changes the diversity and health of the gut microbiota—the trillions of bacteria that live in our intestines and help our immune systems work properly.
Long-term antibiotics can change the mix of bacteria in the gut and may affect how the immune system develops. While these medications help prevent serious infections, researchers need to understand the full picture of how this treatment affects a child's gut health and overall wellness over time.
You likely qualify if…
You likely don't qualify if…
You would provide a stool sample from your child at one or more visits to the research center. The researchers will analyze these samples to study the bacteria in your child's gut and compare them across the three groups. The study is observational, meaning your child will not receive any new treatment or medication as part of this research—it's designed simply to gather information about how the current treatment affects gut health.
AI-generated summary from trial data · Sep 4, 2026 · Not medical advice
France