Plain-English translation of NCT05320796 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing esomeprazole, a common medication that reduces stomach acid and helps prevent ulcers and reflux. The study wants to see how well this medication works in people who have had gastric bypass surgery, and whether it matters if you take it as a tablet or dissolved in liquid. Researchers will measure the medication in your blood and track your stomach acid levels to understand how it works best after this type of surgery.
After gastric bypass surgery, the stomach anatomy changes, which may affect how medications are absorbed and how well they work. This study aims to figure out the best way to give this medication to people after surgery so it can effectively prevent painful ulcers and reflux symptoms.
You likely qualify if…
You likely don't qualify if…
You will have an upper endoscopy exam (a camera test of your stomach), and then a small wireless capsule will be placed in your stomach pouch to monitor acid levels for 48 hours. The next day, you will randomly receive either a tablet or a liquid solution of the medication, and your blood will be drawn at three time points to measure how much medication enters your bloodstream. You'll return the monitoring device after 48 hours, and the study is complete—total time commitment is about 2–3 days.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Switzerland