Plain-English translation of NCT05321745 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing fecal microbiota transplantation (FMT)—a procedure where healthy stool bacteria are transferred into the intestines—combined with a special liquid nutrition formula for children ages 2–16 whose Crohn's disease has not responded to standard treatments. Researchers believe that imbalances in gut bacteria play a major role in Crohn's disease, and this treatment aims to restore healthy bacteria while supporting the child's nutrition and immune system.
Some children with Crohn's disease do not improve with standard medicines like steroids, immune-suppressing drugs, or biologic therapies. This trial exists because early research suggests that restoring healthy gut bacteria through this treatment might help children whose disease is resistant to traditional medications.
You likely qualify if…
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During the treatment phase, your child would continue standard Crohn's disease medications while receiving the fecal microbiota transplants (1–2 times per course, with 3–6 transplants each course) along with the special liquid nutrition formula. In the maintenance phase, the transplants would be repeated every 3 months while gradually reducing standard medications under medical supervision. You would need to attend regular medical visits for monitoring, and the full trial participation would last several months.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
China
Sponsor
Biao Zou
Enrollment target
~40 participants
Started
March 2022
Primary completion
May 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
2 Years – 16 Years
Last updated on clinicaltrials.gov in November 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Biao Zou, doctor
Tongji Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.