Plain-English translation of NCT05325437 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a surgical procedure called laparoscopic splenectomy and azygoportal disconnection can help improve liver function in patients with cirrhosis. Cirrhosis is serious scarring of the liver that makes it harder for the liver to work. The surgery removes the spleen and disconnects certain blood vessels to reduce pressure in the liver and potentially help it recover some of its function.
Patients with cirrhosis often develop complications like an enlarged spleen and bleeding from enlarged veins in the stomach and food pipe. Researchers want to see if this specialized surgery can not only treat these complications but also help the liver itself work better and recover some of its lost function.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would undergo the laparoscopic surgery performed by the study team, followed by care and medications as planned by your doctors. After surgery, you would have follow-up visits and blood tests at 3, 6, 12, and 24 months to measure how well your liver is working. The study team will track specific markers of liver health over these two years to see if the surgery helped improve your liver's function.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
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