Plain-English translation of NCT05331170 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Asthma research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
Researchers are studying how a common cold virus called RV16 affects the airways in people with allergies, asthma, or neither. The study will look at how this virus changes gene activity and airway structure in three groups of people: healthy volunteers, those with hay fever and cat allergies, and those with asthma and cat allergies. This helps scientists understand why some people's immune systems overreact to allergens.
Many people with asthma or allergies have airways that don't work properly, but doctors don't fully understand why catching a cold can make allergies and asthma worse. This research aims to uncover the hidden immune and genetic changes that happen when people with allergies are exposed to viruses, which could lead to better treatments in the future.
You likely qualify if…
You likely don't qualify if…
You will first attend screening visits where doctors will test your lungs, check for allergies, and draw blood to see if you're eligible. If you qualify, you will be exposed to the cold virus RV16 (either through a nasal spray or inhalation) and then monitored as your body responds. Throughout the study, you'll have follow-up visits where researchers collect samples and test your airways to see how the virus affected your immune system and airway structure.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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