Plain-English translation of NCT05338294 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a surgical procedure called laparoscopic splenectomy combined with azygoportal disconnection — a minimally invasive operation to remove the spleen and reduce pressure in blood vessels around the liver. Researchers want to see if this surgery can help restore immune function in people with cirrhosis (advanced liver scarring) who have developed an enlarged spleen and related bleeding problems.
People with cirrhosis often develop a dangerously enlarged spleen that damages their immune system and can cause life-threatening bleeding. This trial is exploring whether removing the spleen through this specialized surgery might help restore immune strength and improve overall health in these patients.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll undergo the minimally invasive surgery performed by the same surgical team. After surgery, you'll receive consistent follow-up care and monitoring. The research team will measure your immune function through blood tests at multiple timepoints: before surgery, and then at 3, 6, 12, and 24 months afterward — tracking white blood cell counts and other immune markers to see how your body responds.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
China
Sponsor
Northern Jiangsu People's Hospital
Enrollment target
~20 participants
Started
March 2022
Primary completion
July 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Guo-Qing Jiang, MD
Clinical Medical College, Yangzhou University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.