Plain-English translation of NCT05343325 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new combination approach for advanced head and neck cancer that hasn't been treated before. You would receive low-dose radiation therapy along with three medications— (an immunotherapy drug), albumin-bound paclitaxel, and cisplatin (both chemotherapy drugs)—before having surgery to remove the cancer. The goal is to see if this combination helps destroy the cancer better than standard treatment alone, with manageable side effects.
Advanced head and neck cancers are difficult to treat and don't always respond well to standard therapies. This trial explores whether combining a newer immunotherapy medication with chemotherapy and radiation before surgery could improve the chance of eliminating the cancer completely.
You would receive treatment over 6 weeks in two cycles of 3 weeks each. During each cycle, you would receive low-dose radiation on specific days, an infusion of , and infusions of the two chemotherapy drugs. About 3–4 weeks after completing these two cycles, you would have surgery to remove the cancer. Throughout the trial, you would have blood tests and scans to monitor how well the treatment is working and to check for side effects.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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