Recruiting

Testing new eye imaging to detect early glaucoma

Plain-English translation of NCT05344274 on ClinicalTrials.gov ↗ · Source last updated December 2025 · Translation generated June 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

Researchers believe that glaucoma — a serious eye disease that can cause vision loss — is linked to problems with blood flow in the retina (the light-sensitive tissue at the back of your eye). This study uses two advanced imaging techniques to directly measure how blood flows through tiny vessels in your eye and how well your eye can regulate that flow. The goal is to see whether these measurements can detect glaucoma damage earlier than current tests, potentially before you notice any vision problems.

Current methods for diagnosing glaucoma often detect the disease only after significant damage has already happened. Researchers believe that problems with blood flow in the eye may occur even earlier, before vision loss appears. If doctors can catch these blood flow problems earlier, they might be able to start treatment sooner and prevent more damage to your sight.

Do you qualify?

You likely qualify if…

you are 18 years or older
you have been diagnosed with early-stage glaucoma, pre-glaucoma (nerve damage without vision loss yet), or you have a healthy eye (for the control group)
you have an open angle in your eye (a specific type of eye anatomy)
your vision is correctable to 20/25 or better with glasses or contacts
you are willing to stop taking glaucoma medications for 4 weeks before and during the study (if applicable to your group)

You likely don't qualify if…

you have corneal problems or other conditions that make eye pressure measurement unreliable
you have other retinal diseases or a history of most types of eye surgery
you have secondary glaucoma (glaucoma caused by another condition) or secondary eye problems
you have smoked in the past 6 months or have diabetes, high blood pressure, or other blood vessel disorders
you have severe cataracts or cannot hold your eye steady enough for imaging scans

What participation looks like

You will visit the research clinic for specialized imaging scans that measure blood flow in your eye using two advanced techniques. One test involves receiving oxygen while researchers measure how your eye's blood vessels respond. The visits involve sitting at imaging equipment and keeping your eye still while cameras take detailed pictures of the tiny blood vessels in your retina. The study compares different groups (early glaucoma, pre-glaucoma, and healthy controls) to see how blood flow patterns differ and whether these measurements predict future vision changes.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(4 sites)

United States

University of Maryland Faculty Physicians, Inc, Baltimore, Maryland

University of Maryland Medical Center, Baltimore, Maryland

University of Maryland, Baltimore, Baltimore, Maryland

Food and Drug Administration (FDA), Silver Spring, Maryland