Recruiting

Testing a stool sample test for detecting colorectal cancer early

Plain-English translation of NCT05346757 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

Read our Colorectal Cancer research guide →

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

The miRFec test is a new screening tool that looks for specific molecular markers in stool samples to identify colorectal cancer and precancerous growths. Researchers are testing whether this test is more effective and cost-effective than the standard fecal test (called FIT) that's currently used for colorectal cancer screening. The goal is to see if this test could become a better option for detecting serious colorectal problems early.

Current screening methods for colorectal cancer don't catch all cases, and some are expensive or inconvenient. This trial aims to develop a more accurate and affordable screening tool that could help more people get diagnosed early, when treatment is most effective.

Do you qualify?

You likely qualify if…

you are age 50–75 and at average risk for colorectal cancer, scheduled for a colonoscopy screening
you are age 30–80 with a family history of colorectal cancer, scheduled for colonoscopy screening
you are age 18 or older with a previous history of colorectal polyps needing follow-up surveillance
you are age 18 or older with a personal history of colorectal cancer needing ongoing surveillance
you are age 18 or older with colorectal symptoms undergoing a diagnostic colonoscopy

You likely don't qualify if…

you have been diagnosed with Lynch syndrome
you have a history of familial polyp syndromes (adenomatous, hamartomatous, or serrated polyposis)
you have inflammatory bowel disease
you have had your entire colon surgically removed
you have a family history of hereditary colorectal cancer syndromes

What participation looks like

If you qualify, you would provide a stool sample that will be analyzed for specific molecular markers using the miRFec test. Your sample results will be compared to findings from your scheduled colonoscopy to see how well the new test performs. The study involves people across multiple medical centers, and your participation helps researchers determine if this test could become a standard screening tool in the future.

AI-generated summary from trial data · Jun 18, 2026 · Not medical advice

Trial locations(1 site)

Spain

Hospital Clinic of Barcelona, Barcelona