Plain-English translation of NCT05349370 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This is a research study designed to understand how the body handles a substance called lactate when patients have septic shock — a life-threatening condition caused by severe infection. Researchers will give you a small amount of specially labeled lactate and then collect multiple blood samples over two hours to track how your body breaks it down. This information will help doctors better understand septic shock and improve future treatment.
When the body is fighting a severe infection, lactate levels rise, and doctors use this as a warning sign of how sick someone is. However, doctors don't fully understand how the body produces and uses lactate during septic shock. This study aims to fill that gap so treatments can be improved.
You likely qualify if…
You likely don't qualify if…
You will receive one injection of a small amount of labeled lactate through your existing arterial catheter. Over the next two hours, researchers will collect 14 small blood samples (2 milliliters each) from that same catheter — samples that would likely be drawn anyway as part of your ICU care. The blood samples are then frozen and analyzed later to measure how your body processes lactate. The entire process takes about two hours.
AI-generated summary from trial data · Sep 24, 2026 · Not medical advice
Sweden
Sponsor
Karolinska University Hospital
Collaborators
Region Stockholm, European Society of Intensive Care Medicine
Enrollment target
~60 participants
Started
December 2022
Primary completion
March 2026
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jonathan Grip, MD, PhD
Karolinska University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.