Plain-English translation of NCT05353946 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Coronary Artery Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two approaches to treating severely calcified (hardened) blockages in heart arteries in patients with chronic kidney disease. One approach uses a specialized rotating device called rotational atherectomy to gently remove the calcium buildup before placing a stent (a small tube to keep the artery open). The other approach uses traditional balloon angioplasty alone. The study aims to see which approach works better, costs less, and causes fewer complications.
People with chronic kidney disease are more likely to develop severely hardened calcium buildup in their heart arteries, which makes them harder to treat and leads to worse health outcomes. While some doctors believe the rotating device approach is safer and more effective, there hasn't been a direct comparison between the two methods in this specific patient population, so doctors need more evidence to know which approach is best.
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If you qualify and join this trial, your doctors will first use imaging (ultrasound or X-ray) to evaluate the hardness and pattern of your artery blockage. Based on what they see, they will decide whether to use the rotating device before placing your stent, or to use traditional balloon treatment. During the procedure, you will be awake but sedated, and the doctors will guide a small catheter through your blood vessels to the blocked artery. After the procedure, you will stay in the hospital briefly and return for follow-up visits to check your health and look for any complications.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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