Plain-English translation of NCT05354622 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Hereditary spastic paraplegia is a group of inherited conditions that affect the nerves controlling leg movement, causing progressive stiffness and weakness. This study aims to identify the genetic causes by analyzing DNA samples from people with the condition, helping researchers understand why symptoms vary so much from person to person.
Many people with hereditary spastic paraplegia experience long diagnostic delays because doctors don't yet know which genes cause the condition or how those genes relate to specific symptoms. This research will help fill that gap by building a large genetic database that could lead to faster diagnoses and better understanding of the disease.
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If you join this study, you will provide a genetic sample (blood or saliva) and detailed information about your medical history and symptoms. The researchers will analyze your DNA to look for genetic variations linked to spastic paraplegia and compare findings across all participants to find patterns. There is no experimental medication or treatment involved — this is purely a research study to gather genetic information.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Enrollment target
~200 participants
Started
April 2022
Primary completion
April 2027
Age range
1 Month – 30 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Darius Ebrahimi-Fakhari, MD, PhD
Boston Children's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.