Plain-English translation of NCT05357794 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether combining two treatments—whole-skin electron beam radiation at very low doses and a medication called —works better for mycosis fungoides than either treatment alone. Mycosis fungoides is a rare type of skin cancer that affects the immune cells in your skin. The researchers want to see how many patients improve with this combination approach and how safe it is.
Mycosis fungoides can be hard to treat, especially when it comes back or stops responding to other therapies. This trial is exploring whether combining this medication with radiation therapy might help more patients get better results and live longer.
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You would receive whole-skin radiation therapy over two days (each session lasting 60 to 90 minutes), and then receive the medication as injections four times over 12 months. The study lasts about 12 months of active treatment, with follow-up visits to check how you're doing, monitor for side effects, and do blood tests. Researchers will also track how well your skin improves, how you feel overall, and any nerve-related side effects from the medication.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
M.D. Anderson Cancer Center
Collaborators
Pfizer
Enrollment target
~30 participants
Started
October 2022
Primary completion
January 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
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Central contact
Bouthaina Dabaja, MD
M.D. Anderson Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.