Plain-English translation of NCT05377216 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are studying how a procedure called a — an injection that temporarily numbs nerves near the neck — affects your heart's electrical system during a heart rhythm ablation procedure. This is an early-phase study designed to understand how this nerve block works and whether it might help protect the heart during ablation treatment.
Dangerous heart rhythms like ventricular tachycardia can be life-threatening, and doctors use ablation procedures to treat them. This study explores whether blocking certain nerves during the procedure might improve outcomes or make the treatment safer and more effective.
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You would receive the injection as part of your scheduled heart ablation procedure at the hospital. The study involves observing how your heart's electrical system responds to this nerve block during and after your ablation treatment. Your doctors will monitor your heart rhythms and may collect blood samples to measure biological changes.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States
Safety & dosing
Sponsor
University of Pennsylvania
Enrollment target
~20 participants
Started
September 2022
Primary completion
July 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in November 2025.
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Central contact
Timothy Markman, MD
University of Pennsylvania
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