Donate blood samples to help researchers understand how blood clot medications work

Recruiting

What is this trial?

Researchers are studying how four blood clot-preventing medications (apixaban, dabigatran, edoxaban, and rivaroxaban) behave in Chinese patients' bodies. When you need to pause one of these medications before a medical procedure like a colonoscopy or heart catheterization, the study team will take blood samples to measure medication levels at different time points after you stop taking it.

Right now, Western guidelines recommend stopping these medications 48 hours before procedures, but the researchers think the medication may work differently in Asian patients and that 24 hours might be enough. This study aims to find out whether stopping the medication for just 24 hours instead of 48 could be safe for Chinese patients.

Do you qualify?

You likely qualify if…

you have been diagnosed with non-valvular atrial fibrillation (an irregular heartbeat condition)
you have been taking one of the study medications for at least 6 months
you are between 18 and 80 years old
you are Chinese or of Chinese descent
you are scheduled for an elective medical procedure that requires you to pause your blood clot medication

You likely don't qualify if…

you have had a blood clot (stroke or other clotting event) or major bleeding while taking this medication
you have severely reduced kidney function (creatinine clearance below 30 mL/min)
you are taking an incorrect dose of your medication based on your age, weight, or kidney function
you are taking this medication for a reason other than atrial fibrillation (such as a heart valve condition or blood clotting disorder)
you have other conditions that affect how your blood clots, besides the medication itself

What participation looks like

When you come in for your scheduled medical procedure, the study team will take blood samples from you at four different time points: at the peak level of your medication, at its lowest level, and 24 and 48 hours after you stop taking it. They will also collect basic health information like your blood pressure, weight, medical history, and a list of all your current medications. The entire process takes place around your regular medical procedure appointment and should not add significantly to your visit time.

How Blood Clot Medications Work in Chinese Patients Before Surgery

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)