Plain-English translation of NCT05378334 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a traditional Chinese herbal medicine called HuGuXiaoJiTang (HGXJT) combined with standard immunotherapy treatment for people with non-small cell lung cancer that has spread to the bones. Half of participants will receive the herbal decoction daily while undergoing their regular immunotherapy and , and half will receive a placebo (a dummy treatment) alongside the same standard care. The study will compare how well the medication works and how safe it is when added to the usual treatment.
Bone metastases—when cancer spreads to the bones—are a serious complication of lung cancer that can cause pain and other problems. Researchers want to see if this traditional herbal remedy can help protect bones and improve outcomes when combined with modern immunotherapy treatments.
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If you join this study, you will receive 4 to 6 cycles of standard immunotherapy and (each cycle is 3 weeks long), followed by ongoing immunotherapy maintenance treatment. At the same time, you will take either the herbal decoction or a placebo once daily for up to one year or until your cancer progresses. You will continue in the study until your tumor gets worse or you have completed one year of treatment, whichever comes first. The study staff will monitor your health regularly to check how well the treatment is working and watch for any side effects.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
China
Sponsor
Guangzhou University of Traditional Chinese Medicine
Enrollment target
~82 participants
Started
June 2022
Primary completion
September 2027
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Wenjie Zhao, Dr
Guangdong Provincial Hospital of Traditional Chinese Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.