Plain-English translation of NCT05384158 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how your brain processes decisions about rewards and losses — things you want versus things you want to avoid. This study will ask you to play simple computer games while your brain activity is measured, and will track how these patterns change over time and after cognitive behavioral therapy, a well-established talk therapy.
Depression, anxiety, and loss of interest often involve problems with how the brain evaluates rewards and losses, making it hard to feel motivated or make decisions. By understanding these brain patterns better, researchers hope to improve how we treat and help people with these conditions.
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You will visit the lab multiple times to play computerized reward and loss games while researchers measure your brain activity with MRI scans. Some sessions will include specific instructions about the games, while others won't — this helps researchers see how instructions change the way your brain works. Some participants will also receive cognitive behavioral therapy during the study. The entire process tracks how your brain's decision-making patterns may shift over time and with treatment.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States