Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

Recruiting

Phase 1 — Early testing in a small group of people (usually 20–80) to evaluate safety, determine safe dosage, and identify side effects.

Trial locations(86 sites)

United States

Providence Medical Foundation, Fullerton, California

California Research Institute, Los Angeles, California

Carle Cancer Center, Urbana, Illinois

Dana-Farber Cancer Institute, Boston, Massachusetts

Henry Ford Hospital, Detroit, Michigan

Miami Valley Hospital South, Centerville, Ohio

Oregon Health & Science University, Portland, Oregon

SCRI Oncology Partners, Nashville, Tennessee

University of Texas MD Anderson Cancer Center, Houston, Texas

UT Health San Antonio University of Texas, San Antonio, Texas

Virginia Cancer Institute, Norfolk, Virginia

Belgium

Antwerp University Hospital, Edegem

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven

Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert

France

Institut de Cancerologie de l'Ouest site Paul Papin, Angers

Hôpital Morvan - CHRU de Brest - cancérologie et d'hématologie, Brest

Centre Francois Baclesse - Oncologie Medicale - Cancerolo, Caen

Centre Jean Perrin, Clermont-Ferrand

Centre Léon Bérard - Département Oncologie Médicale, Lyon

Centre de Cancerologie du Grand Montpellier, Montpellier

Hôpital de la Pitiê Salpêtriêre, Paris

Centre Hospitalier Universitaire de Poitiers, Poitiers

Institut Claudius Regaud, Toulouse

Germany

Klinikum Bayreuth GmbH, Bayreuth

Uniklinik Koeln - Klinik und Poliklinik fuer Frauenheilkunde, Cologne

Universitatsklinikum Carl Gustav Carus, Dresden

Universitaetsklinikum Duesseldorf, Düsseldorf

Universitätsklinikum Erlangen, Erlangen

Medizinische Hochschule Hannover, Hanover

Universitätsklinikum Leipzig, Leipzig

Klinikum Worms gGmbH, Worms

Helios Klinikum Wuppertal, Wuppertal

Greece

National and Capodistrian University of Athens - University General Hospital Attikon, Athens

Metropolitan Hospital [Oncology], Piraeus

EUROMEDICA General Clinic of Thessaloniki, Thessaloniki

Interbalkan European Medical Center, Thessaloniki

Italy

AOU Ospedali Riuniti Umberto I-G.M.Lancisi -G.Salesi, Ancona

Istituto di Candiolo, IRCCS, Candiolo

Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST IRCCS, Meldola

A. O. Ospedali Riuniti Parpardo, Piemonte, Messina, Messina

IEO - Istituto Europeo di Oncologia, IRCCS, Milan

Azienda Ospedaliero-Universitaria di Modena, Policlinico di Modena, Modena

Ospedale San Gerardo, ASST di Monza, IRCCS, Monza

Azienda Ospedaliera Universitaria Federico II, Naples

Istituto Nazionale dei Tumori - Fondazione Pascale, IRCCS, Naples

Istituto Oncologico Veneto IOV - IRCCS, Padova

IRCCS Policlinico San Matteo, Università degli studi di Pavia, Pavia Fondazione IRCCS Policlinico San Matteo, Pavia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

South Korea

Asan Medical Center, Seoul

Gangnam Severance Hospital, Seoul

Samsung Medical Center, Seoul

Ewha Womans University MokDong Hospital, Seoul

Seoul National University Bundang Hospital, Seoul

Seoul National University Hospital, Seoul

Spain

University Hospital Reina Sofía, Córdoba, Andalusia

University Hospital Ramón y Cajal, Madrid, Madrid

University Hospital 12 de Octubre, Madrid, Madrid

Clara Campal Comprehensive Cancer Center (CIOCC), Madrid, Madrid

University Clinical Hospital Virgen de la Arrixaca, El Palmar, Murcia

Hospital Clinic De Barcelona, Barcelona

Hospital Universitari Vall D Hebron, Barcelona

Clinica Universidad de Navarra, Madrid

Hospital Clínico San Carlos, Madrid

Hospital Universitario Quirónsalud Madrid, Madrid

Clinica Universidad de Navarra, Pamplona

Complexo Hospitalario Universitario De Santiago, Santiago de Compostela

Fundación Instituto Valenciano De Oncología, Valencia

Turkey (Türkiye)

Adana Sehir Hastanesi, Adana

Ankara Bilkent Sehir Hastanesi Tibbi Onkoloji Klinigi, Ankara

Ankara University Medical Faculty, Ankara

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Ankara

Gulhane Egitim ve Arastirma Hastanesi Tibbi Onkoloji Klinigi, Ankara

Hacettepe University Medical Faculty, Ankara

Memorial Ankara Hastanesi Tibbi Onkoloji, Ankara

Ege University Medical Faculty, Bornova

Acibadem Altunizade Hospital, Istanbul

Medipol Mega Hospital - Medical Oncology, Istanbul

Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul

United Kingdom

University Hospitals of Leicester NHS Trust -Glenfield Hospital, Leicester

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

Guy's and St Thomas' NHS Foundation Trust, London

University College London Hospitals NHS Foundation Trust - University College Hospital (UCH) - Macmillan Cancer Centre, London

The Christie NHS Foundation Trust - Medical Oncology, Manchester