Plain-English translation of NCT05386108 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Neoplasms research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing whether two medications called and work better when given together to treat breast cancer that has spread to the brain. The study is happening at multiple hospitals around the world and includes two phases: first, doctors will find the safest and most effective dose combination, and then they will test that dose in more patients to see how well it actually works.
Breast cancer that spreads to the brain is very difficult to treat and many standard medications don't reach the brain well enough to help. This trial is exploring whether this medication combination can better penetrate and shrink brain tumors while also being tolerable for patients.
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You will take two pills by mouth every day — the exact doses may vary depending on which group you join and how well you tolerate the treatment. You will have regular visits to the hospital or clinic for blood tests, imaging scans of your brain and body, and check-ins with your doctor to monitor how you are doing and whether your tumors are shrinking. The study involves both a dose-finding phase with fewer patients and a larger testing phase to confirm whether the treatment works.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
United States