Testing a New Medication for Crohn's Disease With Bowel Narrowing

This trial is testing whether ustekinumab, a medication that works on the immune system, can help relieve symptoms and reduce narrowing in the bowel of people with moderate-to-severe Crohn's disease. The study follows patients for up to 2 years, checking how well the medication works using blood tests, imaging scans, and endoscopy. Researchers want to understand which patients benefit most from this treatment and whether it can prevent the need for surgery.

When Crohn's disease causes narrowing (strictures) in the bowel, it can lead to painful blockages and surgery may seem necessary. This trial is exploring whether this medication can shrink those narrowed areas and ease symptoms without requiring an operation, offering patients a medical alternative to surgery.