Plain-English translation of NCT05393518 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to better understand how anxiety disorders develop and affect the brain at the electrical level. This study will use specialized brain recordings (called stereoelectroencephalography, or sEEG) that are already being placed in your brain as part of your epilepsy care, to monitor your brain activity while you experience anxiety-triggering scenarios. By comparing brain patterns in people with and without anxiety disorders, scientists hope to identify the specific brain regions and electrical signatures linked to anxiety.
Current brain imaging studies show which brain areas are involved in anxiety, but they cannot explain exactly how or why anxiety develops. This study fills that gap by directly recording electrical brain activity during anxiety, which is only possible in patients already undergoing these specialized brain recordings for epilepsy surgery planning.
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You will participate while your brain is already being monitored with the intracranial electrodes placed for your epilepsy care. During the study, you will be asked to complete a custom-designed task that exposes you to anxiety-triggering scenarios (such as stressful situations or images). While you do this, researchers will record your brain's electrical activity, measure physical stress signals (like heart rate and breathing), and track how anxious you feel. The study happens in the hospital during your standard pre-surgical monitoring stay.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
France
Sponsor
University Hospital, Bordeaux
Collaborators
Centre National de la Recherche Scientifique, France, Institut National de la Santé Et de la Recherche Médicale, France
Enrollment target
~30 participants
Started
October 2022
Primary completion
October 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in July 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jérôme Aupy, Dr
University Hospital, Bordeaux
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.